Modifying Enzymes
Medchemexpress LLC TC-Mps1-12 | 1206170-62-8 | 99.8% | 324.38 | 100 MG
TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM. It inhibits the growth of pMps1 cell lines and A549 cells in a dose-dependent manner, exhibiting good pharmacokinetic properties.
- Potent and selective Mps1 inhibitor
- Inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay
- Inhibits the growth of A549 cells in a dose-dependent manner in vivo, showing 47% tumor growth inhibition at 100 mg/kg without body weight loss
- Exhibits good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg
Medchemexpress LLC 2,4-Pentadienamide, 5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (2E,4E)- | 1479576 | MFCD15146947 | 99.8% | 273.33 g/mol | C16H19NO3 | 5 MG
Piperlonguminine is an alkaloid amide used in biochemical and pharmacological research to investigate anti-inflammatory, antitumor, neuroprotective, and antimicrobial mechanisms. The reagent is provided as a characterized, research-grade compound with molecular formula C16H19NO3 and molecular weight 273.33 g/mol.
- High purity (99.8%).
- Characterized with analytical data (HNMR, CNMR, LCMS).
- Suitable for in vitro bioactivity screening and mechanistic studies.
- Available in small-vial quantities for screening, e.g., 5 mg.
- Downloadable datasheet, COA, and SDS available.
Creative Biomart Leukocyte Elastase Inhibitor (LEI)
Recombinant Leukocyte Elastase Inhibitor (LEI) Protein(His17-Glu332) is produced by E. coli expression system and fused with two N-terminal Tags, His-tag and T7-tag.
Biotang Inc Cabozantinib,XL184, Free Base, > 99%, M.W. 501.51, C28H24FN3O5, CAS#849217-68-1. RS331-10MG
Cabozantinib,XL184, Free Base, > 99%, M.W. 501.51, C28H24FN3O5, CAS#849217-68-1. RS331-10MG
Biotang Inc Cyclophilin-B Human Recombinant, 10ug
Cyclophilin-B Human Recombinant, Synonyms Peptidylprolyl isomerase B, PPIase, Rotamase, S-cyclophilin, PPIB, cyclophilin-like protein, peptidyl-prolyl cis-trans isomerase B, Cyclophilin B, SCYLP, CYPB, CYP-S1, MGC2224, MGC14109.
Sigma Aldrich Fine Chemicals Biosciences Lipase from Candida rugosa lyophilized powder, >=40,000 units/mg protein | 9001-62-1 | MFCD00131509 | 5MU
Lipase from Candida rugosa lyophilized powder, >=40,000 units/mg protein | 9001-62-1 | MFCD00131509 | 5MU
Sigma Aldrich Fine Chemicals Biosciences Invertase from baker's yeast (S. cerevisiae), 5G
Invertase from baker's yeast (S. cerevisiae). Grade VII, ≥300 units/mg solid. Used in the production of confectionary foods and artificial honey.Biochem/physiol ActionsInvertase hydrolyzes sucrose into glucose and fructose yielding a colorless product, unlike acid hydrolysis which produces colored products.Unit DefinitionOne unit will hydrolyze 1.0 μmole of sucrose to invert sugar per min at pH 4.5 at 55°C.
Sigma Aldrich Fine Chemicals Biosciences Lipase from Pseudomonas cepacia powder, light beige, >=30 U/mg | 9001-62-1 | MFCD00131509 | 100MG
Lipase from Pseudomonas cepacia powder, light beige, >=30 U/mg | 9001-62-1 | MFCD00131509 | 100MG
ABclonal Technology T4 RNA Ligase 2, truncated KQ
T4 RNA Ligase 2, truncated KQ (T4 Rnl2tr R55K, K227Q), specifically catalyzes the ligation of a 5-adenylated DNA or RNA to the 3 OH end of an RNA molecule. This enzyme-mediated ligation does not require ATP but necessitates a pre-adenylated adapter. T4 RNA Ligase 2, truncated KQ, a double-point mutant of T4 RNA Ligase 2 with R55K and K227Q substitutions, significantly reduces the non-specific ligation of RNA (such as concatenation or self-circularization) compared to T4 RNA Ligase 2, truncated, while maintaining enzyme activity similar to that of T4 RNA Ligase 2, truncated.
Cayman Chemical N-Oleoyl-DPPEamonIum salt 10mg
An N-acyl-phosphatidylethanolamine; a biosynthetic precursor to OEA
Discovery Life Sciences HUMAN CYP3A+P450 REDUCTASE
Recombinant enzyme prepared from insect cells infected with baculovirus containing desired cDNAs. CYP3A4 is on average the most abundant P450 in human liver. It is considered the most important P450 for drug metabolism, accounting for the metabolism of 50% or more of prescribed medications. CYP3A4 is also a major isoform in the intestine and can contribute significantly to oral first-pass metabolism of drugs. CYP3A4 metabolizes cortisol, nifedipine, cyclosporin, testosterone, estrogen, (R)-warfarin, gestodene, ketoconazole, miconazole, dapsone, FK-506, quinidine, lovastatin, erythromycin, and numerous other drugs. It is involved in many clinically important drug-drug interactions. CYP3A4 activates aflatoxin B1-related Carcinogens and senecionine. CYP3A4 protein levels can be induced several fold in the liver by ligands of CAR and PXR (e.g., phenobarbital, rifampin, and phenytoin). Contains Human Oxidoreductase and cytochrome b5